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Article

African‐American TOMM40'523‐<i>APOE</i> haplotypes are admixture of West African and Caucasian alleles

25 Sept 2014

Abstract excerpt

BACKGROUND: Several studies have demonstrated a lower apolipoprotein E4 (APOE ε4) allele frequency in African-Americans, but yet an increased age-related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase of Outer Mitochondria Membrane) and APOE depends on accurate TOMM40'523-APOE haplotypes. METHODS: We have compared the APOE and TOMM40'523 phased haplotype...

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PMID: 25260913
DOI: 10.1016/j.jalz.2014.06.009

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