Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotypic Effects of the TOMM40'523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study.

The journal of prevention of Alzheimer's disease - 1 Jan 2023

Zou H, Luo S, Liu H, Lutz M W, Bennett D A, Plassman B L, Welsh-Bohmer K A

Abstract excerpt

BACKGROUND: The 523 poly-T length polymorphism (rs10524523) in TOMM40 has been reported to influence longitudinal cognitive test performance within APOE ε3/3 carriers. The results from prior studies are inconsistent. It is also unclear whether specific APOE and TOMM40 genotypes contribute to heterogeneity in longitudinal cognitive performance during the preclinical stages of AD. OBJECTIVES: To determine the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E3

Share to Apolipoprotein E4

Share to Apolipoproteins E

Share to Cognition

Share to Genotype

Share to Mitochondrial Precursor Protein Import Complex Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 37874111
DOI: 10.14283/jpad.2023.115
PMCID: PMC10734664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotypic Effects of the TOMM40'523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study.PMID 37874111Read ↗

TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype.Semantic proximity Read ↗

TOMM40 '523 Genotype Distinguishes Patterns of Cognitive Improvement for Executive Function in APOEɛ3 Homozygotes.Semantic proximity Read ↗

A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging.Semantic proximity Read ↗

Neuropathologic features of TOMM40 '523 variant on late-life cognitive decline.Semantic proximity Read ↗

Longitudinal modeling of cognitive aging and the TOMM40 effect.Semantic proximity Read ↗

APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans.Semantic proximity Read ↗

Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes.Semantic proximity Read ↗

New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics.Semantic proximity Read ↗

Alzheimer's disease pathology explains association between dementia with Lewy bodies and APOE‐ε4/TOMM40 long poly‐T repeat allele variantsSemantic proximity Read ↗

An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease.Semantic proximity Read ↗

The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes.Semantic proximity Read ↗

Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.