Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans.

PloS one - 1 Jan 2017

Yu Lei, Lutz Michael W, Wilson Robert S, Burns Daniel K, Roses Allen D, Saunders Ann M, Yang Jingyun, Gaiteri Chris, De Jager Philip L, Barnes Lisa L, Bennett David A

Abstract excerpt

Patterns of linkage between the ε4 allele of Apolipoprotein E (APOE) and '523 poly-T alleles in the adjacent gene, TOMM40, differ between Caucasian and African Americans. The extent to which this difference affects the risk of Alzheimer's disease (AD) is unclear. We compared the APOE ε4-TOMM40 '523 haplotypes between older Caucasian and African Americans, and examined their relationship with AD dementia. Data...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Black or African American

Share to Black People

Share to Genetic Linkage

Share to Membrane Transport Proteins

Share to Mitochondrial Precursor Protein Import Complex Proteins

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 28672022
DOI: 10.1371/journal.pone.0180356
PMCID: PMC5495438

Genes

TOMM40
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans.PMID 28672022Read ↗

TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype.Semantic proximity Read ↗

African‐American TOMM40'523‐<i>APOE</i> haplotypes are admixture of West African and Caucasian allelesSemantic proximity Read ↗

Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.Semantic proximity Read ↗

Characterization of the poly-T variant in the TOMM40 gene in diverse populations.Semantic proximity Read ↗

An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease.Semantic proximity Read ↗

Genotypic Effects of the TOMM40'523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study.Semantic proximity Read ↗

Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease.Semantic proximity Read ↗

A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging.Semantic proximity Read ↗

APOE region molecular signatures of Alzheimer's disease across races/ethnicities.Semantic proximity Read ↗

Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease biomarkers.Semantic proximity Read ↗

TOMM40 rs10524523 polymorphism's role in late-onset Alzheimer's disease and in longevity.Semantic proximity Read ↗

Alzheimer's disease pathology explains association between dementia with Lewy bodies and APOE‐ε4/TOMM40 long poly‐T repeat allele variantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.