Article
Characterization of the poly-T variant in the TOMM40 gene in diverse populations.
PloS one - 1 Jan 2012
Linnertz Colton, Saunders Ann M, Lutz Michael W, Crenshaw Donna M, Grossman Iris, Burns Daniel K, Whitfield Keith E, Hauser Michael A, McCarthy Jeanette J, Ulmer Megan, Allingham Rand, Welsh-Bohmer Kathleen A, Roses Allen D, Chiba-Falek Ornit
Abstract excerpt
We previously discovered that a polymorphic, deoxythymidine-homopolymer (poly-T, rs10524523) in intron 6 of the TOMM40 gene is associated with age-of-onset of Alzheimer's disease and with cognitive performance in elderly. Three allele groups were defined for rs10524523, hereafter '523', based on the number of 'T'-residues: 'Short' (S, T≤19), 'Long' (L, 20≤T≤29) and 'Very Long' (VL, T≥30). Homopolymers,...
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