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TOMM40 and APOE variants synergistically increase the risk of Alzheimer's disease in a Chinese population.

Aging clinical and experimental research - 1 Jun 2021

Zhu Zheng, Yang Yang, Xiao Zhenxu, Zhao Qianhua, Wu Wanqing, Liang Xiaoniu, Luo Jianfeng, Cao Yang, Shao Minhua, Guo Qihao, Ding Ding

Abstract excerpt

BACKGROUND: The apolipoprotein E (APOE) ε4 allele is a strong risk factor for Alzheimer's disease (AD) in Caucasian and African American populations. It suggests that other genetic factors may modulate AD pathogenesis in Chinese populations, among which the frequency of this allele is reduced but the AD prevalence is maintained. The translocase of outer mitochondrial membrane 40 (TOMM40), which is located...

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PMID: 32725468
DOI: 10.1007/s40520-020-01661-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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