Article

Association of Rare <i>APOE</i> Missense Variants R189C and W276C With Risk of Alzheimer Disease

2026-05-12

Abstract excerpt

Rare APOE missense variants in admixed populations can clarify mechanisms of Alzheimer disease (AD) risk beyond ε2 and ε4. We analyzed APOE coding variation in the Alzheimer disease Sequencing Project and AllofUs and meta-analyzed ancestry-adjusted case-control associations. Two ε3-linked variants enriched in Native American ancestry among Admixed American individuals were associated with AD: R189C increased ris...

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Literature Corpus work: a04f0908-b240-570b-a717-5ccae0cbc6f1
DOI: 10.64898/2026.05.08.26352778

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