Identifying differential regulatory control of APOE ɛ4 on African versus European haplotypes as potential therapeutic targets.

doi:10.1002/alz.12534

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Article

Identifying differential regulatory control of APOE ɛ4 on African versus European haplotypes as potential therapeutic targets.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2022

Nuytemans Karen, Lipkin Vasquez Marina, Wang Liyong, Van Booven Derek, Griswold Antony J, Rajabli Farid, Celis Katrina, Oron Oded, Hofmann Natalia, Rolati Sophie, Garcia-Serje Catherine, Zhang Shanshan, Jin Fulai, Argenziano Mariana, Grant Struan F A, Chesi Alessandra, Brown Christopher D, Young Juan I, Dykxhoorn Derek M, Pericak-Vance Margaret A, Vance Jeffery M

Abstract excerpt

We previously demonstrated that in Alzheimer's disease (AD) patients, European apolipoprotein E (APOE) ε4 carriers express significantly more APOE ε4 in their brains than African AD carriers. We examined single nucleotide polymorphisms near APOE with significant frequency differences between African and European/Japanese APOE ε4 haplotypes that could contribute to this difference in expression through regulation....

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PMID: 34978147
DOI: 10.1002/alz.12534
PMCID: PMC9250552

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