Article
A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease.
The pharmacogenomics journal - 1 Oct 2010
Roses A D, Lutz M W, Amrine-Madsen H, Saunders A M, Crenshaw D G, Sundseth S S, Huentelman M J, Welsh-Bohmer K A, Reiman E M
Abstract excerpt
The ɛ4 allele of the apolipoprotein E (APOE) gene is currently the strongest and most highly replicated genetic factor for risk and age of onset of late-onset Alzheimer's disease (LOAD). Using phylogenetic analysis, we have identified a polymorphic poly-T variant, rs10524523, in the translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene that provides greatly increased precision in the estimation of...
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