Article

<i>TOMM40</i> ‘523’ genotype induces sex- and tissue- specific differences in cholesterol and triglyceride levels in an <i>APOE-TOMM40</i> humanized mouse model

2026-06-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Genetic variants within the APOE-TOMM40 locus are associated with Alzheimer’s disease (AD). A specific role for TOMM40 is indicated by the finding that ‘523’ poly-T variants are associated with AD risk, but the mechanism for this effect has not been established. Our studies have shown that suppression of Tomm40 in mice increased brain cholesterol content, an AD risk fac...

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Literature Corpus work: 7fbf0165-36bf-5d4c-a05d-53d54ec0b431
DOI: 10.64898/2026.06.09.731195

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