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Article

Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging.

Aging cell - 1 Dec 2014

Arum Oge, Boparai Ravneet K, Saleh Jamal K, Wang Feiya, Dirks Angela L, Turner Jeremy G, Kopchick John J, Liu Jun-Li, Khardori Romesh K, Bartke Andrzej

Abstract excerpt

In addition to their extended lifespans, slow-aging growth hormone receptor/binding protein gene-disrupted (knockout) (GHR-KO) mice are hypoinsulinemic and highly sensitive to the action of insulin. It has been proposed that this insulin sensitivity is important for their longevity and increased healthspan. We tested whether this insulin sensitivity of the GHR-KO mouse is necessary for its retarded aging by...

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Identifiers

PMID: 25244225
DOI: 10.1111/acel.12262
PMCID: PMC4326932

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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