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Article

Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.

Endocrine reviews - 1 Jun 2011

List Edward O, Sackmann-Sala Lucila, Berryman Darlene E, Funk Kevin, Kelder Bruce, Gosney Elahu S, Okada Shigeru, Ding Juan, Cruz-Topete Diana, Kopchick John J

Abstract excerpt

Disruption of the GH receptor (GHR) gene eliminates GH-induced intracellular signaling and, thus, its biological actions. Therefore, the GHR gene disrupted mouse (GHR-/-) has been and is a valuable tool for helping to define various parameters of GH physiology. Since its creation in 1995, this mouse strain has been used by our laboratory and others for numerous studies ranging from growth to aging. Some of the...

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Identifiers

PMID: 21123740
DOI: 10.1210/er.2010-0009
PMCID: PMC3365798

Genes

GHR

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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