Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulin and aging

1 Nov 2008

Abstract excerpt

In invertebrates, signaling pathways homologous to mammalian insulin and insulin-like growth factor (IGF-1) signal transduction have a major role in the control of longevity. There are numerous indications that these pathways also influence aging in mammals, but separating the role of insulin from the effects of IGF-1 and growth hormone (GH) is difficult. In mice, selective disruption of the insulin receptor in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apelin-related biomedical research
Share to Birth, Development, and Health
Share to Genetics, Aging, and Longevity in Model Organisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18948730
DOI: 10.4161/cc.7.21.7012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin and agingPMID 18948730Read ↗

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humansSemantic proximity Read ↗

Role of insulin/insulin-like growth factor 1 signaling pathway in longevitySemantic proximity Read ↗

Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends LifespanSemantic proximity Read ↗

The insulin/IGF-1 signaling in mammals and its relevance to human longevity.Semantic proximity Read ↗

Minireview: Role of the Growth Hormone/Insulin-Like Growth Factor System in Mammalian AgingSemantic proximity Read ↗

[Hyperinsulinemia and aging].Semantic proximity Read ↗

Tissue‐specific insulin signaling in the regulation of metabolism and agingSemantic proximity Read ↗

Studies of Caenorhabditis elegans DAF‐2/insulin signaling reveal targets for pharmacological manipulation of lifespanSemantic proximity Read ↗

The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogasterSemantic proximity Read ↗

Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?Semantic proximity Read ↗

Human insulin/IGF-1 and familial longevity at middle ageSemantic proximity Read ↗

The role of insulin/IGF-like signaling in C. elegans longevity and agingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.