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Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females

12 Oct 2016

Abstract excerpt

GH and IGF-1 are important for a variety of physiological processes including growth, development, and aging. Mice with reduced levels of GH and IGF-1 have been shown to live longer than wild-type controls. Our laboratory has previously found that mice with a GH receptor gene knockout (GHRKO) from conception exhibit low rates of cancer, resistance to diet-induced diabetes, and extension of lifespan. The GHRKO...

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PMID: 27732088
DOI: 10.1210/en.2016-1649

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