Article
Mutation in IR or IGF1R produces features of long-lived mice while maintaining metabolic health.
JCI insight - 22 Dec 2025
Hernández-Arciga Ulalume, Kim Jun Kyoung, Fisher Jacob L, Tyshkovskiy Alexander, Moldakozhayev Alibek, Hall Catherine, Ghosh Souvik, Govindaraj Yashvandhini, Sipula Ian J, Kastroll Jake, Cooke Diana, Luo Jinping, Alder Jonathan K, Rizzo Stacey J Sukoff, Ables Gene P, Choi Eunhee, Gladyshev Vadim N, Jurczak Michael J, Tatar Marc, Parkhitko Andrey A
Abstract excerpt
Insulin/insulin growth factor signaling is a conserved pathway that regulates lifespan. However, long-lived loss-of-function mutants often produce insulin resistance, slow growth, and impair reproduction. Recently, a gain-of-function mutation in the kinase insert domain (KID) of the Drosophila insulin/IGF receptor was seen to dominantly extend lifespan without impairing insulin sensitivity, growth, or...
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