Article

Beta-cell adaptation to metabolic stresses requires prolactin receptor signaling

2024-01-23

Abstract excerpt

The role of prolactin receptor (PRLR) signaling in β-cell adaptation to maternal insulin resistance of pregnancy has been well demonstrated. Using transgenic mice with an inducible β-cell-specific Prlr deletion (βPrlr -/- ), we found that intact PRLR, as found in βPrlr +/+ mice, were protected from developing glucose intolerance during pregnancy, and the main mechanism responsible for this PRLR-mediated effect i...

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Literature Corpus work: ca823795-bea0-5465-b42a-1a8ced416fa3
DOI: 10.1101/2024.01.20.575603

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