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Article

Probing the relationship between insulin sensitivity and longevity using genetically modified mice.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Dec 2012

Nelson James F, Strong Randy, Bokov Alex, Diaz Vivian, Ward Walter

Abstract excerpt

Interference in insulin and/or insulin-like growth factor 1 (IGF-1) signaling can extend invertebrate life span, and interference in IGF-1 signaling can extend murine life span. Whether interference with murine insulin signaling, which can be diabetogenic and pathological, is also life-extending is controversial. We therefore measured life span in 3 murine strains genetically modified to reduce or increase...

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PMID: 23089336
DOI: 10.1093/gerona/gls199
PMCID: PMC3670160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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