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Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells

27 Jun 2023

Abstract excerpt

Introduction The enhanced β-cell senescence that accompanies insulin resistance and aging contributes to cellular dysfunction and loss of transcriptional identity leading to type 2 diabetes (T2D). While senescence is among the 12 recognized hallmarks of aging, its relation to other hallmarks including altered nutrient sensing (insulin/IGF1 pathway) in β-cells is not fully understood. We previously reported that...

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PMID: 37441495
DOI: 10.3389/fendo.2023.1203534

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