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Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan

1 Jul 2017

Abstract excerpt

The causal relationships between insulin levels, insulin resistance, and longevity are not fully elucidated. Genetic downregulation of insulin/insulin-like growth factor 1 (Igf1) signaling components can extend invertebrate and mammalian lifespan, but insulin resistance, a natural form of decreased insulin signaling, is associated with greater risk of age-related disease in mammals. We compared Ins2 +/− mice to...

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PMID: 28700945
DOI: 10.1016/j.celrep.2017.06.048

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