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Article

Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation.

Aging cell - 1 Feb 2014

Xu Jie, Gontier Géraldine, Chaker Zayna, Lacube Philippe, Dupont Joëlle, Holzenberger Martin

Abstract excerpt

Growth hormone (GH) and insulin-like growth factor (IGF) signaling regulates lifespan in mice. The modulating effects of genetic background gained much attention because it was shown that life-prolonging effects in Snell dwarf and GH receptor knockout vary between mouse strains. We previously reported that heterozygous IGF-1R inactivation (IGF-1R(+/-) ) extends lifespan in female mice on 129/SvPas background, but...

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Identifiers

PMID: 23898955
DOI: 10.1111/acel.12145
PMCID: PMC4326867

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Source receipt: pubmed, retrieved 7 Sept 2026.

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