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Article

Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity

1 Apr 2013

Abstract excerpt

Growth hormone (GH) is a key determinant of postnatal growth and plays an important role in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling delays aging and remarkably extends longevity in laboratory mice. In GH-deficient and GH-resistant animals, the "healthspan" is also extended with delays in cognitive decline and in the onset of age-related disease. The role of...

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Share to Birth, Development, and Health
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Identifiers

PMID: 23589828
DOI: 10.1152/physrev.00006.2012

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