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Minireview: Role of the Growth Hormone/Insulin-Like Growth Factor System in Mammalian Aging

27 May 2005

Abstract excerpt

The important role of IGF and insulin-related signaling pathways in the control of longevity of worms and insects is very well documented. In the mouse, several spontaneous or experimentally induced mutations that interfere with GH biosynthesis, GH actions, or sensitivity to IGF-I lead to extended longevity. Increases in the average life span in these mutants range from approximately 20-70% depending on the...

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PMID: 15919742
DOI: 10.1210/en.2005-0411

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