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Article

Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk.

Human genetics - 1 Dec 2014

Wang Xuting, Pittman Gary S, Bandele Omari J, Bischof Jason J, Liu Gang, Brothers John F, Spira Avrum, Bell Douglas A

Abstract excerpt

Chronic cigarette smoking exposes airway epithelial cells to thousands of carcinogens, oxidants and DNA-damaging agents, creating a field of molecular injury in the airway and altering gene expression. Studies of cytologically normal bronchial epithelial cells from smokers have identified transcription-based biomarkers that may prove useful in early diagnosis of lung cancer, including a number of p53-regulated...

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Identifiers

PMID: 25179167
DOI: 10.1007/s00439-014-1483-8
PMCID: PMC4225167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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