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Article

RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs.

BMC pulmonary medicine - 5 Mar 2018

Yeo Jiyoun, Morales Diego A, Chen Tian, Crawford Erin L, Zhang Xiaolu, Blomquist Thomas M, Levin Albert M, Massion Pierre P, Arenberg Douglas A, Midthun David E, Mazzone Peter J, Nathan Steven D, Wainz Ronald J, Nana-Sinkam Patrick, Willey Paige F S, Arend Taylor J, Padda Karanbir, Qiu Shuhao, Federov Alexei, Hernandez Dawn-Alita R, Hammersley Jeffrey R, Yoon Youngsook, Safi Fadi, Khuder Sadik A, Willey James C

Abstract excerpt

BACKGROUND: There is a need for more powerful methods to identify low-effect SNPs that contribute to hereditary COPD pathogenesis. We hypothesized that SNPs contributing to COPD risk through cis-regulatory effects are enriched in genes comprised by bronchial epithelial cell (BEC) expression patterns associated with COPD. METHODS: To test this hypothesis, normal BEC specimens were obtained by bronchoscopy from 60...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29506519
DOI: 10.1186/s12890-018-0603-y
PMCID: PMC5838965

Genes

ERCC5
CAT
GPX1
KEAP1
XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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