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Article

Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression.

PloS one - 21 May 2009

Rotunno Melissa, Yu Kai, Lubin Jay H, Consonni Dario, Pesatori Angela C, Goldstein Alisa M, Goldin Lynn R, Wacholder Sholom, Welch Robert, Burdette Laurie, Chanock Stephen J, Bertazzi Pier Alberto, Tucker Margaret A, Caporaso Neil E, Chatterjee Nilanjan, Bergen Andrew W, Landi Maria Teresa

Abstract excerpt

Polymorphisms in genes coding for enzymes that activate tobacco lung carcinogens may generate inter-individual differences in lung cancer risk. Previous studies had limited sample sizes, poor exposure characterization, and a few single nucleotide polymorphisms (SNPs) tested in candidate genes. We analyzed 25 SNPs (some previously untested) in 2101 primary lung cancer cases and 2120 population controls from the...

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Identifiers

PMID: 19479063
DOI: 10.1371/journal.pone.0005652
PMCID: PMC2682568

Genes

EPHX1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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