Article
Transcriptome-wide association study reveals candidate causal genes for lung cancer.
International journal of cancer - 1 Apr 2020
Bossé Yohan, Li Zhonglin, Xia Jun, Manem Venkata, Carreras-Torres Robert, Gabriel Aurélie, Gaudreault Nathalie, Albanes Demetrius, Aldrich Melinda C, Andrew Angeline, Arnold Susanne, Bickeböller Heike, Bojesen Stig E, Brennan Paul, Brunnstrom Hans, Caporaso Neil, Chen Chu, Christiani David C, Field John K, Goodman Gary, Grankvist Kjell, Houlston Richard, Johansson Mattias, Johansson Mikael, Kiemeney Lambertus A, Lam Stephen, Landi Maria T, Lazarus Philip, Le Marchand Loic, Liu Geoffrey, Melander Olle, Rennert Gadi, Risch Angela, Rosenberg Susan M, Schabath Matthew B, Shete Sanjay, Song Zhuoyi, Stevens Victoria L, Tardon Adonina, Wichmann H-Erich, Woll Penella, Zienolddiny Shan, Obeidat Ma'en, Timens Wim, Hung Rayjean J, Joubert Philippe, Amos Christopher I, McKay James D
Abstract excerpt
We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal of our study has been to integrate the complete GWAS results with a large-scale expression quantitative trait loci (eQTL) mapping study in human lung tissues (n = 1,038) to identify candidate causal genes for lung cancer. We performed transcriptome-wide association study (TWAS) for...
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