Article
Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.
Proceedings of the National Academy of Sciences of the United States of America - 3 May 2005
Tomso Daniel J, Inga Alberto, Menendez Daniel, Pittman Gary S, Campbell Michelle R, Storici Francesca, Bell Douglas A, Resnick Michael A
Abstract excerpt
The p53 tumor suppressor protein is a master regulatory transcription factor that coordinates cellular responses to DNA damage and cellular stress. Besides mutations in p53, or in proteins involved in the p53 response pathway, genetic variation in promoter response elements (REs) of p53 target genes is expected to alter biological responses to stress. To identify SNPs in p53 REs that may modify p53-controlled...
Topics
- Base Sequence
- Cell Line, Tumor
- Computational Biology
- DNA, Complementary
- Gene Expression Regulation
- Genome, Human
- Humans
- Luciferases
- Mutagenesis, Site-Directed
- Plasmids
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic