Functional diversity in the gene network controlled by the master regulator p53 in humans.

Abstract excerpt

Individual differences in susceptibility to exposure induced diseases are likely due to variation in the DNA sequences of "environmental response" genes, many of which are arranged in complex regulatory networks. Among approximately 10 million inherited DNA variations, called single nucleotide polymorphisms (SNPs), perhaps only a few thousand, will actually influence human disease risk. We have combined...

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