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Article

Identifying polymorphic cis-regulatory variants as risk markers for lung carcinogenesis and chemotherapy responses in tobacco smokers from eastern India.

Scientific reports - 10 Mar 2023

Sengupta Debmalya, Mukhopadhyay Pramiti, Banerjee Souradeep, Ganguly Kausik, Mascharak Prateek, Mukherjee Noyonika, Mitra Sangeeta, Bhattacharjee Samsiddhi, Mitra Ritabrata, Sarkar Abhijit, Chaudhuri Tamohan, Bhattacharjee Gautam, Nath Somsubhra, Roychoudhury Susanta, Sengupta Mainak

Abstract excerpt

Aberrant expression of xenobiotic metabolism and DNA repair genes is critical to lung cancer pathogenesis. This study aims to identify the cis-regulatory variants of the genes modulating lung cancer risk among tobacco smokers and altering their chemotherapy responses. From a list of 2984 SNVs, prioritization and functional annotation revealed 22 cis-eQTLs of 14 genes within the gene expression-correlated DNase I...

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PMID: 36899086
DOI: 10.1038/s41598-023-30962-9
PMCID: PMC10006236

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