Article
Single nucleotide polymorphism in transcriptional regulatory regions and expression of environmentally responsive genes.
Toxicology and applied pharmacology - 1 Sept 2005
Wang Xuting, Tomso Daniel J, Liu Xuemei, Bell Douglas A
Abstract excerpt
Single nucleotide polymorphisms (SNPs) in the human genome are DNA sequence variations that can alter an individual's response to environmental exposure. SNPs in gene coding regions can lead to changes in the biological properties of the encoded protein. In contrast, SNPs in non-coding gene regulatory regions may affect gene expression levels in an allele-specific manner, and these functional polymorphisms...
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