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Identifying polymorphic cis-regulatory variants as risk markers for lung carcinogenesis and chemotherapy responses in tobacco smokers from Eastern India

2022-07-11

Abstract excerpt

Aberrant expression of xenobiotic metabolism and DNA repair genes is critical to lung cancer pathogenesis. This study aims to identify the cis-regulatory variants of the genes modulating lung cancer risk among tobacco smokers and altering their chemotherapy responses. From a list of 2984 SNVs, prioritization and functional annotation of 22 cis-eQTLs of 14 genes present within the gene expression-correlated DNase I...

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Literature Corpus work
d90d17b1-aac4-504b-86e5-f9e9ac8a5a8d
DOI
10.21203/rs.3.rs-1842337/v1
Open publication

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Identifying polymorphic cis-regulatory variants as risk markers for lung carcinogenesis and chemotherapy responses in tobacco smokers from Eastern IndiaDOI 10.21203/rs.3.rs-1842337/v1
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