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Article

Human paraoxonase 1 hydrolysis of nanomolar chlorpyrifos-oxon concentrations is unaffected by phenotype or Q192R genotype.

Toxicology letters - 1 Oct 2014

Coombes R Hunter, Meek Edward C, Dail Mary Beth, Chambers Howard W, Chambers Janice E

Abstract excerpt

The organophosphorus insecticide chlorpyrifos has been widely used. Its active metabolite chlorpyrifos-oxon (CPO) is a potent anticholinesterase and is detoxified by paraoxonase 1 (PON1). PON1 activity is influenced by numerous factors including a Q192R polymorphism. Using forty human blood samples bearing homozygous genotypes and either high or low activity phenotypes (as determined by high concentration assays...

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Identifiers

PMID: 25093614
DOI: 10.1016/j.toxlet.2014.07.029
PMCID: PMC4817274

Genes

CPO
PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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