Article
Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds.
Journal of biochemical and molecular toxicology - 1 Jan 2007
Furlong Clement E
Abstract excerpt
Detoxication of organophosphorus (OP) compounds is affected by genetic and environmental modulation of a number of enzymes involved in the process. For organophosphorothioate insecticides, different P450 isozymes and variants carry out two reactions that have quite different consequences; (1) they bioactivate their parent compounds to highly toxic oxon forms that are many times more toxic than the parent...
Topics
- Amino Acid Substitution
- Animals
- Arginine
- Aryldialkylphosphatase
- Catalysis
- Genetic Variation
- Humans
- Inactivation, Metabolic
- Isoenzymes
- Mice
- Mice, Knockout
- Mice, Transgenic
- Microsomes, Liver
- Models, Biological
- Organophosphate Poisoning
- Organophosphorus Compounds
- Polymorphism, Genetic
- Recombinant Proteins