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Article

Paraoxonase and susceptibility to organophosphorus poisoning in farmers dipping sheep.

Pharmacogenetics - 1 Feb 2003

Mackness Bharti, Durrington Paul, Povey Andrew, Thomson Stuart, Dippnall Martin, Mackness Mike, Smith Ted, Cherry Nicola

Abstract excerpt

OBJECTIVES: Human serum paraoxonase (PON1) hydrolyses organophosphate pesticides (OPs) entering the blood circulation and tissue fluid thus limiting toxicity. The PON1 coding region has two polymorphisms involving the amino acids at position 55 (Lt<--M) and 192 (Qt<--R), giving rise to isoenzymes which differ in their catalytic rate for the hydrolysis of OPs. We therefore hypothesized that individuals inheriting...

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Source

Identifiers

PMID: 12563177
DOI: 10.1097/00008571-200302000-00004

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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