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Article

Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects.

Chemico-biological interactions - 20 Jul 2007

Sirivarasai Jintana, Kaojarern Sming, Yoovathaworn Krongtong, Sura Thanyachai

Abstract excerpt

Paraoxonase (PON1) plays an important role in mechanism of organophosphorus compound (OP) toxicity, as seen both in vitro and in vivo studies. Polymorphisms of PON1 gene at coding and promoter regions have also been to affect on the hydrolytic activity and PON1 level. The objectives of this study were to determine PON1 polymorphism and activity in an OP-exposed population and the effects on inhibition of...

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Identifiers

PMID: 17532308
DOI: 10.1016/j.cbi.2007.04.006

Genes

PON1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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