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Article

Genetically determined susceptibility to organophosphorus insecticides and nerve agents: developing a mouse model for the human PON1 polymorphism.

Neurotoxicology - 1 Jan 2000

Furlong C E, Li W F, Costa L G, Richter R J, Shih D M, Lusis A J

Abstract excerpt

Several organophosphorus insecticides and nerve agents are detoxified through the cytochrome P450/paraoxonase (PON1) pathway. PON1 is an HDL-associated enzyme encoded as a 355 amino acid protein in humans. The PON1 Arg192 isoform hydrolyzes paraoxon rapidly while the Gln192 isoform hydrolyzes thi...

Topics

Acetylcholinesterase
Alleles
Animals
Aryldialkylphosphatase
Brain
Chemical Warfare Agents
Chlorpyrifos
Diaphragm
Esterases
Humans
Insecticides
Isoenzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Mice, Transgenic

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Identifiers

PMID: 9745924

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9745924-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Genetically determined susceptibility to organophosphorus insecticides and nerve agents: developing a mouse model for the human PON1 polymorphism.PMID 9745924Read ↗

Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity.Semantic proximity Read ↗

Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds.Semantic proximity Read ↗

Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants.Semantic proximity Read ↗

The PON1 gene and detoxication.Semantic proximity Read ↗

Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism.Semantic proximity Read ↗

Human paraoxonase 1 hydrolysis of nanomolar chlorpyrifos-oxon concentrations is unaffected by phenotype or Q192R genotype.Semantic proximity Read ↗

The ratio of serum paraoxonase/arylesterase activity using an improved assay for arylesterase activity to discriminate PON1(R192) from PON1(Q192).Semantic proximity Read ↗

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The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status.Semantic proximity Read ↗

Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds.Semantic proximity Read ↗

Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype.Semantic proximity Read ↗

Paraoxonase 1 status as a risk factor for disease or exposure.Semantic proximity Read ↗

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