Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity.

Toxicology - 10 May 2013

Costa Lucio G, Giordano Gennaro, Cole Toby B, Marsillach Judit, Furlong Clement E

Abstract excerpt

Paraoxonase (PON1) is an A-esterase capable of hydrolyzing the active metabolites (oxons) of a number of organophosphorus (OP) insecticides such as parathion, diazinon and chlorpyrifos. PON1 activity is highest in liver and in plasma. Human PON1 displays two polymorphisms in the coding region (Q192R and L55M) and several polymorphisms in the promoter and the 3'-UTR regions. The Q192R polymorphism imparts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryldialkylphosphatase
Share to PON1 gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 22884923
DOI: 10.1016/j.tox.2012.07.011
PMCID: PMC3516631

Genes

PON1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity.PMID 22884923Read ↗

Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds.Semantic proximity Read ↗

Effect of organophosphate intoxication on human serum paraoxonase.Semantic proximity Read ↗

Genetically determined susceptibility to organophosphorus insecticides and nerve agents: developing a mouse model for the human PON1 polymorphism.Semantic proximity Read ↗

Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects.Semantic proximity Read ↗

Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity.Semantic proximity Read ↗

Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism.Semantic proximity Read ↗

Paraoxonase-1 (PON1) Status Analysis Using Non-Organophosphate Substrates.Semantic proximity Read ↗

Paraoxonase 1 status as a risk factor for disease or exposure.Semantic proximity Read ↗

Bayesian meta-analysis of inter-phenotypic differences in human serum paraoxonase-1 activity for chemical risk assessment.Semantic proximity Read ↗

Role of paraoxonase 1 (PON1) in organophosphate metabolism: implications in neurodegenerative diseases.Semantic proximity Read ↗

Determination of paraoxonase 1 status and genotypes at specific polymorphic sites.Semantic proximity Read ↗

Pharmacogenetics of paraoxonases: a brief review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.