Article
Bayesian meta-analysis of inter-phenotypic differences in human serum paraoxonase-1 activity for chemical risk assessment.
Environment international - 1 May 2020
Darney K, Kasteel E E J, Buratti F M, Turco L, Vichi S, Béchaux C, Roudot A C, Kramer N I, Testai E, Dorne J L C M, Di Consiglio E, Lautz L S
Abstract excerpt
Human variability in paraoxonase-1 (PON1) activities is driven by genetic polymorphisms that affect the internal dose of active oxons of organophosphorus (OP) insecticides. Here, an extensive literature search has been performed to collect human genotypic frequencies (i.e. L55M, Q192R, and C-108T) in subgroups from a range of geographical ancestry and PON1 activities in three probe substrates (paraoxon, diazoxon...
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