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Article

The Relationship between PON1 phenotype and PON1-192 genotype in detoxification of three oxons by human liver.

Drug metabolism and disposition: the biological fate of chemicals - 1 Feb 2007

Mutch Elaine, Daly Ann K, Williams Faith M

Abstract excerpt

Phosphorothioate pesticides (OP) such as diazinon, chlorpyrifos, and parathion are activated to highly toxic oxon metabolites by the cytochromes P450 (P450s), mainly in the liver. Simultaneously, the P450s catalyze detoxification of OP to nontoxic dearylated metabolites. The oxon is then detoxified to the dearylated metabolite by PON1, an A-esterase present in the liver and blood serum. The aims of this study...

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Source

Identifiers

PMID: 17132760
DOI: 10.1124/dmd.106.013193

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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