Article
Non-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast cancer.
PloS one - 1 Jan 2014
Kunická Tereza, Václavíková Radka, Hlaváč Viktor, Vrána David, Pecha Václav, Rauš Karel, Trnková Markéta, Kubáčková Kateřina, Ambruš Miloslav, Vodičková Ludmila, Vodička Pavel, Souček Pavel
Abstract excerpt
OBJECTIVES: ATP-Binding Cassette (ABC) transporters may cause treatment failure by transporting of anticancer drugs outside of the tumor cells. Multidrug resistance-associated protein 1 coded by the ABCC1 gene has recently been suggested as a potential prognostic marker in breast cancer patients. This study aimed to explore tagged haplotype covering nucleotide binding domain 1 of ABCC1 in relation with...
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