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Article

Germline variant burden in multidrug resistance transporters is a therapy‐specific predictor of survival in breast cancer patients

3 Feb 2020

Abstract excerpt

Multidrug resistance due to facilitated drug efflux mediated by ATP-binding cassette (ABC) transporters is a main cause for failure of cancer therapy. Genetic polymorphisms in ABC genes affect the disposition of chemotherapeutics and constitute important biomarkers for therapeutic response and toxicity. Here we correlated germline variability in ABC transporters with disease-specific survival (DSS) in 960 breast...

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PMID: 32010961
DOI: 10.1002/ijc.32898

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