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Article

Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): effects on its expression and clinicopathological characteristics in breast cancer patients.

Pharmacogenetics and genomics - 1 Mar 2008

Vaclavikova Radka, Nordgard Silje H, Alnaes Grethe I G, Hubackova Miluse, Kubala Eugen, Kodet Roman, Mrhalova Marcela, Novotny Jan, Gut Ivan, Kristensen Vessela N, Soucek Pavel

Abstract excerpt

OBJECTIVES: Resistance of tumor cells to multiple cytostatic agents is one of the major impediments of successful cancer chemotherapy. A large part of resistance of tumors to chemotherapy is caused by the ABC transporter P-glycoprotein encoded by the ABCB1 gene. The main aim of this study was to assess the prognostic value of ABCB1 genotype and phenotype in breast cancer. METHODS: Six ABCB1 single nucleotide...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple

Share to Drug Resistance, Neoplasm

Share to Oligonucleotide Array Sequence Analysis

Share to Pharmacogenetics

Share to Receptors, Estrogen

Share to RNA, Neoplasm

Source

Identifiers

PMID: 18300948
DOI: 10.1097/FPC.0b013e3282f60a91

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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