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ABC transporters in breast cancer: their roles in multidrug resistance and beyond

26 Jun 2022

Abstract excerpt

ATP-binding cassette (ABC) transporters are membrane-spanning proteins involved in cholesterol homeostasis, transport of various molecules in and out of cells and organelles, oxidative stress, immune recognition, and drug efflux. They are long implicated in the development of multidrug resistance in cancer chemotherapy. Existing clinical and molecular evidence has also linked ABC transporters with cancer...

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PMID: 35758271
DOI: 10.1080/1061186x.2022.2091578

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