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Article

High expression of ATP-binding cassette transporter ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival.

Breast cancer research and treatment - 1 Feb 2013

Yamada Akimitsu, Ishikawa Takashi, Ota Ikuko, Kimura Mariko, Shimizu Daisuke, Tanabe Mikiko, Chishima Takashi, Sasaki Takeshi, Ichikawa Yasushi, Morita Satoshi, Yoshiura Koh-ichiro, Takabe Kazuaki, Endo Itaru

Abstract excerpt

ATP-binding cassette (ABC) transporters are membrane proteins that efflux various compounds from cells, including chemotherapeutic agents, and are known to affect multidrug resistance. Recent reports disagree on whether ABCC11 is a risk factor for breast tumorigenesis, but its expression in breast cancer is poorly investigated. We hypothesized that both frequency and expression levels of ABC transporters in...

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Source

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Identifiers

PMID: 23288347
DOI: 10.1007/s10549-012-2398-5
PMCID: PMC3560367

Genes

ABCC11
ABCC1
ABCG2
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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High expression of ATP-binding cassette transporter ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival.PMID 23288347Read ↗

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Role of Genetic Variation in ABC Transporters in Breast Cancer Prognosis and Therapy Response.Semantic proximity Read ↗

The Expression Profile of Atp-Binding Cassette Transporter Genes in Breast CarcinomaSemantic proximity Read ↗

ABC gene expression profiles have clinical importance and possibly form a new hallmark of cancerSemantic proximity Read ↗

ABCC11 expression is regulated by estrogen in MCF7 cells, correlated with estrogen receptor expression in postmenopausal breast tumors and overexpressed in tamoxifen-resistant breast cancer cellsSemantic proximity Read ↗

Non-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast cancer.Semantic proximity Read ↗

The effect of ABCB1 polymorphisms on the outcome of breast cancer treatmentSemantic proximity Read ↗

ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistanceSemantic proximity Read ↗

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