Article
ABCC1 G2012T single nucleotide polymorphism is associated with patient outcome in primary neuroblastoma and altered stability of the ABCC1 gene transcript.
Pharmacogenetics and genomics - 1 May 2011
Pajic Marina, Murray Jayne, Marshall Glenn M, Cole Susan P C, Norris Murray D, Haber Michelle
Abstract excerpt
OBJECTIVE: Multidrug resistance is a major cause of treatment failure in neuroblastoma. Multidrug resistance protein 1 has been previously implicated in the development of drug resistance, particularly with regard to influencing clinical outcomes in neuroblastoma. Numerous single nucleotide polymorphisms (SNPs) in the gene encoding multidrug resistance protein 1, namely ATP-binding cassette sub-family C member 1...
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