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Article

The effect of ABCB1 polymorphisms on the outcome of breast cancer treatment

1 Apr 2016

Abstract excerpt

The ABCB1 gene encodes a permeability glycoprotein, which is one of the most extensively studied human adenosine-triphosphate (ATP)-dependent efflux transporters. Permeability glycoprotein is expressed in the apical membranes of tissues such as intestine, liver, blood-brain barrier, kidney, placenta, and testis and contributes to intracellular drug disposition. It is also highly expressed in tumor cells...

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PMID: 27175090
DOI: 10.2147/pgpm.s86672

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