Article
Roles of ABCB1 gene polymorphisms and haplotype in susceptibility to breast carcinoma risk and clinical outcomes.
Journal of cancer research and clinical oncology - 1 Sept 2012
Wu Huizhe, Kang Hui, Liu Yong, Tong Weiwei, Liu Duo, Yang Xiuli, Lian Minqiong, Yao Weifan, Zhao Haishan, Huang Desheng, Sha Xianzheng, Wang Enhua, Wei Minjie
Abstract excerpt
PURPOSE: Genetic variants of ABCB1 gene contributed to cancer susceptibility and interindividual differences in chemotherapy response. Therefore, we investigated the relevance between genetic variations in ABCB1 gene and both risk and clinical outcomes of breast carcinoma. METHODS: A case-control study was performed on the SNPs C3435T, C1236T and G2677T/A in 1,173 Chinese breast carcinoma patients and 1,244 age-...
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