Article
Role of Genetic Variation in ABC Transporters in Breast Cancer Prognosis and Therapy Response.
International journal of molecular sciences - 15 Dec 2020
Hlaváč Viktor, Václavíková Radka, Brynychová Veronika, Koževnikovová Renata, Kopečková Katerina, Vrána David, Gatěk Jiří, Souček Pavel
Abstract excerpt
Breast cancer is the most common cancer in women in the world. The role of germline genetic variability in ATP-binding cassette (ABC) transporters in cancer chemoresistance and prognosis still needs to be elucidated. We used next-generation sequencing to assess associations of germline variants in coding and regulatory sequences of all human ABC genes with response of the patients to the neoadjuvant cytotoxic...
Topics
- ATP-Binding Cassette Transporters
- Alleles
- Antineoplastic Combined Chemotherapy Protocols
- Biomarkers, Tumor
- Breast Neoplasms
- Female
- Gene Frequency
- Genetic Variation
- Genotype
- High-Throughput Nucleotide Sequencing