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Article

Importance of ABCC1 for cancer therapy and prognosis

26 Mar 2014

Abstract excerpt

Multidrug resistance presents one of the most important causes of cancer treatment failure. Numerous in vitro and in vivo data have made it clear that multidrug resistance is frequently caused by enhanced expression of ATP-binding cassette (ABC) transporters. ABC transporters are membrane-bound proteins involved in cellular defense mechanisms, namely, in outward transport of xenobiotics and physiological...

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PMID: 24670052
DOI: 10.3109/03602532.2014.901348

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