Article
Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians.
The Journal of pharmacology and experimental therapeutics - 1 Dec 2005
DeLozier Tracy C, Lee Soo-Chin, Coulter Sherry J, Goh Boon Cher, Goldstein Joyce A
Abstract excerpt
CYP2C9 was recently resequenced in 150 Asian subjects from Singapore. Several new coding variants were reported, and these variants are now named CYP2C9*14 (R125H), CYP2C9*15 (S162X), CYP2C9*16 (T299A), CYP2C9*17 (P382S), CYP2C9*18 (D397A), and CYP2C9*19 (Q454H). The CYP2C9*18 variant also contained an I359L change previously associated with the CYP2C9*3 allele. In this study, we assessed the functional...
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