Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro and in vivo characterization of 13 CYP2C9 allelic variants found in Chinese Han population.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2015

Hu Guo-Xin, Pan Pei-Pei, Wang Zeng-Shou, Yang Li-Ping, Dai Da-Peng, Wang Shuang-Hu, Zhu Guang-Hui, Qiu Xiang-Jun, Xu Tao, Luo Jun, Lian Qing-Quan, Ge Ren-Shan, Cai Jian-Ping

Abstract excerpt

Our previous study detected totally 35 CYP2C9 allelic variants in 2127 Chinese subjects, of whom 21 novel alleles were reported for the first time in Chinese populations. The aim of the present study was to characterize the 13 CYP2C9 allelic variants both in vitro and in vivo. Different types of CYP2C9 variants were highly expressed in COS-7 cells, and 50 μM tolbutamide was added as the probing substrate to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Area Under Curve
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, High Pressure Liquid

Share to COS Cells

Share to Cytochrome P-450 CYP2C9

Share to Genetics, Population

Share to Plasmids

Share to Transfection

Source

Identifiers

PMID: 25614704
DOI: 10.1124/dmd.114.061200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro and in vivo characterization of 13 CYP2C9 allelic variants found in Chinese Han population.PMID 25614704Read ↗

In vitro functional characterization of 37 CYP2C9 allelic isoforms found in Chinese Han population.Semantic proximity Read ↗

In vitro assessment of 36 CYP2C9 allelic isoforms found in the Chinese population on the metabolism of glimepiride.Semantic proximity Read ↗

Discovery of new potentially defective alleles of human CYP2C9.Semantic proximity Read ↗

Distribution of CYP2C9*13 allele in the Chinese Han and the long-range haplotype containing CYP2C9*13 and CYP2C19*2.Semantic proximity Read ↗

Identification and drug metabolic characterization of four new CYP2C9 variants CYP2C9*72-*75 in the Chinese Han populationSemantic proximity Read ↗

Effect of 36 CYP2C9 variants found in the Chinese population on losartan metabolism in vitro.Semantic proximity Read ↗

Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese.Semantic proximity Read ↗

CYP2C9 polymorphism analysis in Han Chinese populations: building the largest allele frequency database.Semantic proximity Read ↗

Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians.Semantic proximity Read ↗

Functional characterization of 32 CYP2C9 allelic variants.Semantic proximity Read ↗

In vitro metabolism of phenytoin in 36 CYP2C9 variants found in the Chinese population.Semantic proximity Read ↗

Identification and functional characterization of 11 novel CYP2C19 variants in the Chinese Han population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.